Evaluation of Anti-Diabetic Activity of Silver Nanoparticles Synthesized from Ethanolic Extract of Phyllanthus niruri on Wistar Rats

Diabetes is a metabolic disorder characterized by hyperglycemia resulting from either the deficiency in insulin secretion or action of can affect numerous different organ systems body and, over time, lead to serious complications. Complications are microvascular macrovascular. To evaluate anti-diabetic effect Phyllanthus niruri silver nano-particles. Streptozotocin (STZ) 50mg/kg used induce diabetes wistar rats. The rats were distributed six groups. Group-I represented as Control; Group-II diabetic control (STZ ); Group-III 5 mg/kg weight glibenclamide + diabetes; Group-IV phyllanthus extract Group-V 100 µg nanoparticles group-6- nanoparticles150µg diabetes. inspected for morphological and optical properties investigated using UV spectrophotometer, SEM FT-IR techniques. AgNPs has shown characteristic peak at 428nm.The study revealed that treatment reduced serum blood glucose concentrations remarkable improvement weight, Abnormal high levels with AgNp’s they reached normal STZ-challenged histo-pathological alterations also studied all experimental animals. pathology results induces regeneration islets cells pancreas research proved exerts properties.
 Keywords: Diabetes, STZ, niruri,